| P01 ADMET and Toxicology |
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A Rapid Assay for p450 Inhibition/Induction Utilizing Ultra Performance Liquid Chromatography & Tandem Quadrupole Mass Spectrometry
View Abstract |
An AlphaLISA® Workstation – A Complete Solution for Immunoassay Simplification, Improved Performance, Maximized Throughput, Increased Sensitivity, & Assay Cost Reduction
View Abstract |
An Automated LC/MS/MS Protocol To Enhance Throughput of Physico-Chemical Property Profiling In Drug Discovery
View Abstract |
Application of Cellular Systems Biology to Cytotoxicity Profiling
View Abstract |
CellCiphr – Cellular Systems Biology Assay for Hepatotoxicity Using Human HepG2 Cells
View Abstract |
CYP450 Inhibition Profiling Using High-Throughput RapidFire Mass Spectrometry Assays
View Abstract |
Distribution of Cytochrome P450 Activity Across Known Drugs & Diverse Compound Collections
View Abstract |
Hepatocyte Culture Performance is Improved Over Current Methods When Cells are Grown On A Synthetic ECM-Mimetic Surface Topography
View Abstract |
Identification of Cytochrome P450 Mechanism-Based Inhibitors Using In vitro High-Throughput Assay
View Abstract |
In vitroToxicity Screening by Transcription Factor Activity Profiling
View Abstract |
Overt Toxicity Screening Assay Using Live Z-TagSM Zebrafish
View Abstract |
Predictive Cytotoxicity Measurements by Monitoring Heat Shock Proteins & the Cell Cycle in High-content Screening Cell-Based Assays
View Abstract |
Stratgies to Reduce the Number of True Genotoxins Proceeding to Animal Testing
View Abstract |
The Use of Multi-Parametric High-Content Screening Assays to Monitor Cytotoxicity & Different Programmed Cell Death Pathways.
View Abstract |
The Use of Quantitative, Cell-based, High-Content Screening Assays to Detect In vitro Genotoxicity & the Effect on Cell Cycle Checkpoints
View Abstract |
Validation of Automated High-Throughput Plasma Protein Binding Assays
View Abstract |
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| P02 Advances in Assay Technology |
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A Functional Assay for Gq-coupled GPCRs by Measuring Inositol Monophospate-1 in 1536-well Plate format
View Abstract |
A General Method for Discovering Inhibitors of Protein-DNA Interactions Using Photonic Crystal Biosensors
View Abstract |
A Genome-wide siRNA Screen for Identifying Novel Genes Involved in Maintaining Genomic Stability
View Abstract |
A High-Throughput Permeability Screening Methodology Utilizing a Novel Artificial PAMPA Membrane & LC/MS/MS Detection
View Abstract |
A New Aquesous Solubility Screen High-Throughput Sonication
View Abstract |
A Novel Fluorimetric Assay for Detection of TACE (Ą-secretase) Activity Using a Long Wavelength FRET Peptide Substrate
View Abstract |
A Novel Incubation Procedure to Reduce Edge-Effect in High-Throughput Cell-Based Assays
View Abstract |
A Novel Non-Fluorescent Quencher Dye Quenching a Broad Range of Fluorophores & Its Implementation in Protease Activity Assays
View Abstract |
A Sensitive & Simple Homogeneous QRET Technology for Biomolecular Screening
View Abstract |
A Surface Plasmon Resonance Based Assay for the Detection & Characterization of Promiscuous Inhibitors
View Abstract |
An Assessment of Multiple Fluorescence Calcium Indicator Dyes in Three Diverse Recombinant Systems By Measurement in A Flipr Cell-Based Calcium Flux Assay
View Abstract |
Antibody-free Lck Kinase Fluorescence Lifetime Assay
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Abstract |
Application of EpicÒ System in Cell-based Assays
View Abstract |
Application of plex-in-plex Branched DNA Assay in Quantitating mRNA in Early Drug Discovery
View Abstract |
Applying The Labcyte MicroClime Lid In Biological Assays To Improve Data Quality & Quantity.
View Abstract |
Assessment of the Immune Response Using High-content Screening Cell-based Imaging & Antibody Arrays
View Abstract |
Automatic Recptor Trafficking Assay Analysis using Machine Learning
View Abstract |
Automation & Miniaturization of Immunoassays for Drug Discovery AlphaLISA®, a Sensitive No-Wash Assay
View Abstract |
Automation of Pre-coated PAMPA Plates Improves Predictability, Reproducibility, & Efficiency
View Abstract |
Cell-Permeable Fluorogenic Oligonucleotides Single Cell RNA Profiling, Antisense & siRNA Delivery, & Live Cell Imaging
View Abstract |
Cellular Protein Dynamics Studied With Covalently Labeling Protein Tags
View Abstract |
Comparison of a Cellular ELISA & AlphaScreen SureFire™ for Evaluation of Ligand Stimulated ERK Phosphorylation in Human Umbilical Vein Endothelial Cells
View Abstract |
Comparison of An Alphalisa Assay vs. ECL & ELISA Assays to Measure Abeta40 & Abeta42 Levels for HTS & Lead Optimization
View Abstract |
Cyclic Olefin Polymer is a Superior Material For High-Density Multiwell Microtiter Plate Construction
View Abstract |
Detection of Caspase-3/7 Activity in Human Serum & Plasma as a Potential Biomarker of Apoptotic Cell Death Using the Promega Caspase-Glo® 3/7 Assay
View Abstract |
Detection of Ligand-Dependent Interaction of Nuclear Receptors with their Cofactor Using the Corning® Epic® System
View Abstract |
Development & Validation of a Protein-Protein Interaction HTS Assay Based on AlphaLisa™ Technology
View Abstract |
Development of 8 New No-Wash Immunoassay Kits for the Detection of VEGF, Amyloid Beta1-40, Amyloid Beta1-42, Insulin, Human IgG, EPO, HIV p24 & TNFalpha Using PerkinElmer AlphaLISA
View Abstract |
Development of a Non Binding Surface for Biochemical Assays & High-Throughput Screening
View Abstract |
Development of a Plasma Based Assay for Endothelial Lipase
View Abstract |
Development of Customized Immunoassays using AlphaLISA®
View Abstract |
Division Arrested Cells Simplifying Assay Design & Increasing Flexibility
View Abstract |
Drug-Drug Interactions of Human Cytochrome P450s by a New Electrochemical Array
View Abstract |
Dynamic Protein Affinity Chromatography SPE-LC-MS Finding New Receptor Ligands in Complex Mixtures
View Abstract |
Evaluation of AequoZen™ Frozen Cells Starter Kit using the Aequorin Option for the FLIPR TETRA® System
View Abstract |
ExpressLC – A Platform For Fast, Reliable Separation-Based Assays Using Microflow LC Separations & Nanoliter Volume Detection
View Abstract |
FMAT Based Assay to Detect Antibodies Against Cell Surface Receptors
View Abstract |
GDP Detection Using the Transcreener Technology
View Abstract |
GPCR Screening and Profiling Using Arrestin Reveals Unique Pharmacology for Compounds on Known Receptors and Provides a Platform For Oprhan GPCRs in Discovery and Repositioning Applications
View Abstract |
HIF-Prolyl Hydroxylase; Preparation of Multiple Reagents to Develop TR-FRET Assay for HTS
View Abstract |
High-Density STEP Array Plates A Novel Platform for Multiplexed GPCR Screening
View Abstract |
High-Throughput Assays for de novo DNA Synthesis using Click Chemistry Detection Technology
View Abstract |
High-Throughput Cell Migration Assay with the IsoCyte™ Laser Scanning Platform
View Abstract |
HTS Flow Cytometry of Multiplexed Targets HTS Flow Cytometry
View Abstract |
Immobilized Bead Assay System For Multiple Analyte Detection
View Abstract |
Improvements in Data Quality & Assay Performance Using Aequorin for Calcium Based Screening.
View Abstract |
Introducing the CellKey™384 System, A Label-Free High-Throughput Cell-Based Assay for Functional Screening of Cellular Receptors
View Abstract |
Label Free Holographic Biosensors for Drug Discovery
View Abstract |
Label-Free Antibody Screening Sandwich Assay Using the Corning Epic® System
View Abstract |
Label-Free Determination of Kinetic Constants for Small Molecule Binding to Proteins Using FortéBio’s Octet RED Multi-Channel System
View Abstract |
Label-Free Optical Biosensor for Probing GPCR Ligand-Directed Functional Selectivity
View Abstract |
Label-Free Optical Biosensor for Probing Receptor Biology Theory, Modeling & Applications
View Abstract |
LipoSignal A Homogeneous, Cell-Free Assay for Screening for Modulators of GPCR Activation
View Abstract |
Maintaining 1536 Well Assay-Ready Microplate Reagent Integrity Using An Automatable Microplate Lid That Provides An Environmental Barrier Seal
View Abstract |
Microchannel Assays Using Primary Tumor Cells, Co-culture & 3-dimensional Extracellular Matrices
View Abstract |
Multiplexing HCV Replicon Luciferase Assay With Cell-Titer Blue Toxicity Assay In HTS Format
View Abstract |
nanoCF™ Assay System A Novel Tool for Mechanistic Studies
View Abstract |
nanoCF™ Assay system A Novel Tool for Mechanistic Studies
Part Two Compound Profiling & Mechanism of Action
View Abstract |
New SA-PE Conjugates Improve Critical Assay Parameters in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology
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Abstrac |
New SA-PE Conjugates Reduce Capture-Antibody-Specific Background in Sandwich Immunoassays Performed Using Luminex® xMAP® Technology
View Abstract |
Novel Ratiometric Phospholipase A2 Specific Enzyme Substrate with a Fluorescence Donor & Acceptor Pair
View Abstract |
Old Assays, New Instrument The Omega - High Speed, UV/Vis Spectrometer in a Microplate Reader
View Abstract |
Optimizing Nucleic Acid Detection by Altering Detection Chemistry
View Abstract |
PhotoScreen™ luminescent Calcium Assays Applications on LumiLux® & FLIPRTETRA®
View Abstract |
Profiling for GPCR activation using DiscoveRx PathHunter B-Arrestin Technology
View Abstract |
Profiling the Activity of Proteasome Inhibitors Using Promega’s Proteasome-Glo™ Cell-Based Assay
View Abstract |
QT Prolongation Assay Using Beating Cardiomyocyte Derived From Monkey ES Cell
View Abstract |
Quest Rhod-4™ Calcium Indicator, a New Red Fluorescent for Screening GPCR & Calcium Channel Targets
View Abstract |
Receptor Selection & Amplification Technology A Unique, Powerful Screening Platform for Drug Discovery
View Abstract |
Ru TR-FRET Assays Evaluation of Two Acceptor Dyes & Comparison with Eu TR-FRET Assays
View Abstract |
Selective Detection of Pyrophosphate Using a Fluorogenic Pyrophosphate Sensor
View Abstract |
Stem Cell-Derived Neurons In CNS Drug Discovery
View Abstract |
Targeting & manipulating the STAT, M1-NFAT, & NFêB signaling pathways in quantitative high-throughput screening (qHTS) using a laser-scanning fluorescence microplate cytometer
View Abstract |
Template-Directed Self-Assembly Imparts Biological Relevance to Standard In vitro Assays
View Abstract |
The CellKey™384 System Enables High-Throughput Screening with a Label-free Cell-Based Assay Platform.
View Abstract |
Utilizing Techniques in Developing & Optimizing Assay Paradigms to Increase Throughput in Screening Small Libraries & Special Compound Collections
View Abstract |
Validation of a Functional Screening Assay for Glycine Transporter 1 Inhibitors Using Cryopreserved Cells
View Abstract |
Watchmaker® - Compound Generation by Combinatorial Genetics & Screening in Yeast
View Abstract |
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| P03 Automation and Detection Platforms |
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A Story in Method Transfer Troubleshooting Accuracy Matters When Transferring Quantitative, Manually-pipetted Assays to Automation
View Abstract |
Advances in Automated Transporter Screening Parallelization Approach leads to Eight-Fold Increase in Throughput
View Abstract |
Advances in Genomic Screening Through High-Throughput Viral Production
View Abstract |
Advances in High-Throughput Screening with the New LumiLux® CS Cellular luminescence Platform.
View Abstract |
An Automated Method for the Expansion & Neural Differentiation of Embryonic Stem Cells
View Abstract |
An Integrated Solution for Efficient Enzyme Panel Screening
View Abstract |
Automated High-Throughput Drug Discovery Using Surface Plasmon Resonance
View Abstract |
Automatic Transfluor Assay Analysis using Machine Learning
View Abstract |
Development of the Octet RED System for Label-Free, Multi-channel Kinetic Analysis of Biomolecular Interactions
View Abstract |
Duplex HTS Assay Measured Simultaneously With Nano-TRF & fluorescence Lifetime Method
View Abstract |
Evaluation of the New EnVision Monochromator Option
View Abstract |
Hamamatsu Photonic FDSS7000 The New uHTS System with Multi-Dispense & Multi-Detection mode.
View Abstract |
High-Throughput Automation of Cisbio’s IP-One HTRF® Assay using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection Platform
View Abstract |
High-Throughput Secondary Screening—1400 Dose-Response Curves per Hour
View Abstract |
Increasing Efficiency & Maintaining Quality Running HTS on a 24/7 Schedule.
View Abstract |
Integration of a Labcyte Echo 550 Liquid H&er® with a Velocity 11 Element System™
View Abstract |
KingFisher® Flex – Flexible Automated Nucleic Acid, Protein & Cell Purification
View Abstract |
Label-Free Characterization of Proteins Using Acoustic Droplet Ejection Deposition & Advanced X-Ray Technology Measurement
View Abstract |
Optimizing Performance of the Transcreener™ ADP Assay for Commonly Used Multiwell Readers
View Abstract |
Performing Cytotoxicity Assays with Sleeping Cells & Thermo Scientific Microplate Readers
View Abstract |
Robust Kinetic Characterization of Moving Objects for Subcellular Time-lapse Assays
View Abstract |
Screening & Development of Antibodies For Use in High-content Immunofluorescent Microscopy.
View Abstract |
Slide-based Miniaturized Microtiter Plate for ELISA & Cell-based Assays
View Abstract |
The Synergy Family of Readers, A Lower Cost High Performance Alternative for Running AlphaScreen Assays
View Abstract |
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| P04 Biopharmaceuticals |
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Rapid Selective In Situ Screening Of Hybridomas in Semisolid Medium
View Abstract |
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| P05 Cells and Proteins in Drug Discovery |
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A Multiplex Approach to Characterization of RTK & ERK Pathway Signaling
View Abstract |
A New Approach to Cell-Based Assays Mouse Embryonic Neural Stem Cells
View Abstract |
Automation of AlphaLISA Insulin & VEGF Immunoassays on JANUS Liquid Handling Workstation
View Abstract |
Bioactive Coatings For Stem Cell Homing & Its Applications In Heart Valve Tissue Engineering
View Abstract |
Cell Factory. Production of cryopreserved cells as reagents for screening assays.
View Abstract |
Development of Label Free Cellular Assays Using Primary Neuronal Cells
View Abstract |
Dimerization of BZIP Proteins in Living Cells Assayed by Fluorescence Imaging Technology
View Abstract |
Frozen Cells in Assay Plates for Instant Use in Cell-Based Screening
View Abstract |
Frozen Human Primary Cells for High-Throughput Screening
View Abstract |
One Stop Total Cell-Based Assay Solution with Invitrogen From Assay Validation to High-Throughput Screening in Few Weeks
View Abstract |
Production of Biologically Active Chemokines In E. Coli
View Abstract |
SPR Imaging, a Label-Free Method for the Analysis of Microarrays
View Abstract |
The Application of Microcarrier Technology to The Provision of Receptor Membranes For High-Throughput Screening
View Abstract |
The Impact of Automated Clone Selection on the Cell Line Generation Process
View Abstract |
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| P06 Compound Management |
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A Modular Solution For Long Term Storage of Biological Samples
View Abstract |
A new Paradigm in Sample Library Management & Replication
View Abstract |
Facing the Challenges of Supplying Assay Ready Plates Utilizing Special Library Sets to Obtain Novel Leads for the Hit to Lead Phase of Drug Discovery
View Abstract |
Maintaining the Integrity of the Wyeth Liquid Samples
View Abstract |
Speeding the Compound Processing along the Research Super Highway
View Abstract |
Storage Solutions New Technologies, New Applications
View Abstract |
Successful Implementation of a Bio-Sample Store
View Abstract |
The Great Transfer
View Abstract |
Use of PocketTip for Both Compound Storage & Screening
View Abstract |
Validation of Low Volume 1536 “Assay Ready” Compound Plates for a Nuclear Hormone Receptor Screen.
View Abstract |
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| P07 Data Processing and Analysis |
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Beyond Biomolecular Screening A Multi-Parametric Procedure for Efficient Hit & Lead Identification
View Abstract |
Creative Ways to Increase our Screening Capacity in a Production Environment.
View Abstract |
Data Processing & Quality Assurance in a Kinetic Enzyme Assay
View Abstract |
HistopatholgicalSpectrum of Thymic Neoplasms Nine-years Research Survey at a SAL Hospital, Ahmedabad, India
View Abstract |
M-Screen An Open-Source, Web-Based Application Package that Integrates Compound Management & High-Throughput Screening (HTS) Data Analysis
View Abstract |
Mining Biological Screening Data in PubChem
View Abstract |
Spatio-Temporal Cell Segmentation & Tracking for Automated Screening
View Abstract |
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| P08 High Content Screening |
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A Heterogeneous Angiogenesis Assay Using Primary Cell Co-Culture In Microchannels
View Abstract |
A High-content Homogeneous Assay for P-Glycoprotein Inhibition using Microplate Cytometry
View Abstract |
A New Fluorescent Mitochondrial Membrane Potential Sensor for Imaging & Fluorescence Plate Reader-Based Applications
View Abstract |
Assessment of PI3-Kinase & AKT Signaling Using Quantitative Cell-Based Immunofluorescence High-content Screening Assays
View Abstract |
Brightfield as a Label Free Adjunct to Fluorescence High-content Screening for Improved Assay Performance & Data Quality
View Abstract |
Cell Cycle Drug Profiling by BrdU Incorporation, Histone H3 Phosphorylation, Cytoskeletal Rearrangement, & Cell Morphology Changes by Multiplexed High-Content Screening Assays
View Abstract |
Complete Automated Solution for HLA Antibody Detection Using Multiplex xMAP Technology
View Abstract |
Compound Selectivity & Specificity Profiling Using Functional Protein Microarrays
View Abstract |
Determination of Lipid Droplet Accumulation in Oleic Acid Treated Cells Using The Acumen eX3
View Abstract |
Full Automation of Magnetic Bead-Based Luminex xMAP Cytokine Assays on the PerkinElmer JANUS® Automated Liquid Handling Platform
View
Abstract |
High-content Image Analysis Using a Laser Scanning Microplate Cytometer
View Abstract |
High-content Screening Assays for Neurotoxicity Profiling
View Abstract |
High-content Screening Enables High-Throughput Screening
View Abstract |
High-throughput DNA Damage Assay for Breast Cancer Related Protein Markers using the IsoCyte™ Platform
View Abstract |
High-Throughput Fluorescence Lifetime Based Assays for Protein Kinases
View Abstract |
Imaging PML Nuclear Bodies Using a High-content Imaging Platform
View Abstract |
Intracellular Nitric Oxide (NO) Generation Rates Correlate With Different No Synthases’ Expression Levels, At The Resolution of Individual Living Cells
View Abstract |
Label-free Analysis of Tissue Sections & Cells Using Laser Scanning Reflectance Imaging
View Abstract |
Multiplexed High-content Screening Assays for Cell Cycle Analysis & Cytotoxicity Profiling
View Abstract |
Navigating the High-content Imaging Process
View Abstract |
PamChip Peptide Micro Array Technology Applications in Kinase & Nuclear Receptor Research
View Abstract |
Processware - An Order of Magnitude Improvement in LIMS Technology
View Abstract |
Quantitative Analysis of Angiogenesis & Cytoskeletal Formation with IN Cell Investigator
View Abstract |
Quantitative High-Content Analysis of Intracellular Oxidative Stress & DNA Damage
View Abstract |
Rapid Screening of 250 Supernatants Using Multiplexed SPR Technology & Real-Time Double Referencing
View Abstract |
Screening for Estrogen Receptor á (ERá) Ligands Using Nuclear Translocation Analysis
View Abstract |
Sub-Cellular Resolution Genome Wide RNA Interference Analysis Within A Day
View Abstract |
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| P09 Liquid Handling and Microfluidics |
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Automated Low Volume Cell Dispensing & Analysis Using the BioRAPTR FRD Microfluidic Workstation & PARADIGM™ Detection Platform for cAMP & Ion Channel Assays
View Abstract |
Best Practices for Assessing Nanoliter Transfer Performance for Acoustic Droplet Ejection Liquid H&lers
View Abstract |
Differential Cell Adhesion Within An Isogenic Model Of Melanoma Progression Under Shear Flow Conditions Using Cellix’s Venafluxtm Platform
View Abstract |
Evaluation of Nanoliter Transfer using Acoustic Droplet Ejection
View Abstract |
High-Throughput Kinase Selectivity Profiling for Drug Discovery Applications
View Abstract |
Improving the efficiency of 384 “mini-tube” Technology Using Mosquito® nanolitre pipetting
View Abstract |
Improving the Efficiency Of 384 “mini-tube” Technology Using Mosquito® Nanolitre Pipetting
View Abstract |
Liquid Delivery Errors – The Impact of Laboratory Conditions on Pipetting Performance
View Abstract |
Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution using mosquito ®
View Abstract |
Low Volume Liquid Handling of Organic Solvents for Compound Storage & Dissolution Using mosquito ®
View Abstract |
PCR Set Up in LightCycler® Carousels Using VERSA Workstations
View Abstract |
Real-time Reaction Monitoring & Enzyme Kinetics Measurements on the ExpressLC platform
View Abstract |
The Effects of Pipette Tip Material & Sterilization on the Retention of Aqueous Liquids
View Abstract |
Toward Routine Assays in 200 nL Volumes
View Abstract |
Utilizing Nano25 Low Volume Dispenser for Hit Optimization
View Abstract |
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| P10 Structural Bio - Lib Design and Lead Opt |
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Antimalarial Drug Discovery From Target Validation to Lead Qualification
View Abstract |
Atomic-level Structural & Kinetic Analysis of Integral Membrane Protein Binding Interactions
View Abstract |
Structural Mapping Of Gpcr Interactions With Ligands, Drugs, & Antibodies
View Abstract |
What Structural Features Explain why Some Fragments of the Molecule are Important While Others are not?
View Abstract |
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| P11 Target Biology and Screening GPCRs |
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A New Robust No-Wash FLIPR Calcium Assay Kit for Screening GPCR & Calcium Channel Targets
View Abstract |
A New Technology for G-protein Coupled Receptors Analysis Conformational Specific Antibodies.
View Abstract |
Adrenergic Receptor Family Membrane Preparation Array With Millipore's MultiScreenHTS Glass Fiber Filter Plates
View Abstract |
Aequorin Plasmids A Novel Tool for Generating Cell Lines for Luminescence Assays
View Abstract |
An Aequorin Luminescence-Based Assay for Monitoring GPCR Function in Cryopreserved CHO Cells Transiently Expressing Either a Receptor-of-Interest or Apo-aequorin-3
View Abstract |
An RGS protein HTS assay Strategy using the Transcreener™ GDP Assay
View Abstract |
Biosensor Screening & Analysis of GPCR Interaction Kinetics
View Abstract |
Building the Predictor™ Fluorescence Polarization Assay for High-Throughput Screening of hERG Channel Affinity
View Abstract |
Comparison of Aequorin to Flourescent Dye for GPCR Calcium Flux Using Cells Transfected With The Human Free Fatty Acid (FFA1) Receptor (GPR40).
View Abstract |
Comparison of Photina® Luminescent Calcium Mobilization Assays on both the FlexStation 3® & the FLIPRTETRA® Systems
View Abstract |
Determination of a Galpha/i-coupled Receptor Activity Using CISBIO’s Membrane-based cAMP HiRange® kit
View Abstract |
Development of a Panel of cAMP Hunter™ Cell Lines for Analysis of Naturally Coupled GPCRs Using the DiscoveRx HitHunter™ cAMP Detection Kits.
View Abstract |
Direct Fluorescent Labelling Approaches for G-protein Coupled Receptors & Imaging Using the Opera™ High-Content Screening Platform
View Abstract |
Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor 8 (mGluR8) using GIRK-mediated Thallium Flux Modulation in High-Throughput Screening
View Abstract |
Dual Purpose Cell Lines for Analysis of GPCR/Arrestin Interaction Using PathHunter & Natural Gq-coupling Using the Improved Calcium No-Wash PLUS Kit.
View Abstract |
Endogenous Receptor Characterization in Normal Lung Cells by Cellular Dielectric Spectroscopy & RNA Interference
View Abstract |
Establishment of Functional Assays that Discriminate Between Neutral Antagonists & Inverse agonists
View Abstract |
HitHunter™ cAMP Assays Versatile Assays Validated for Multiple Applications
View Abstract |
Identification of GPR23 Agonists, Antagonists & Inverse Agonists by High-throughput Screening
View Abstract |
Improvements in GPCR & calcium channel screening using Second Generation BD Calcium Assay Kits
View Abstract |
Introduction of a new TR-FRET Terbium Cryptate IP-One Tb, a new generation HTRF® kit applied to GPCR Screening & Investigation
View Abstract |
Label-Free Cell-Based Screening for GPCR Agonists & Antagonists using the Corning® Epic® System
View Abstract |
Label-Free Optical Biosensor for Probing the Roles of Adenylate Cyclases in Signaling Integration of G Protein-Coupled Receptors
View Abstract |
Leveraging Early Liability & Drug Safety Assessment by Integration of Innovative Screening Automation, High-Throughput Reagent Generation & Novel Bioassay Technology
View Abstract |
Miniaturization of the HitHunter™ cAMP XS+ Assay for Gs/Gi Screening in 1536 Well Plate Format.
View Abstract |
New Aequorin Parental Cell Lines for Screening of GPCRs
View Abstract |
Unveiling Drug Selectivity Via Functional Profiling & Multi-Prong Approach To Hit Validation Using ChemiScreen™ GPCR Cell Lines
View Abstract |
Utilization of PathHunter Arrestin Cell Lines for Detection of Arrestin Biased Ligands & Compound Pharmacology Distinct from Second Messengers.
View Abstract |
Validation of Different Aequorin Mutants for GPCR Screening Using the FLIPRTETRA® System with Aequorin Option
View Abstract |
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| P12 Target Biology and Screening Ion Channels |
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An Automated Microfluidic Dose-Response System for Ion Channels
View Abstract |
An Ion Channel FLIPR HTS Using the New Fluo-8 Calcium Dye
View Abstract |
Optimization of High-Throughput Ion Channel Screens Using Single Cell & Population Analyses
View Abstract |
Primary Human Cells & BacMam Target Delivery in a Novel, High-Throughput Assay of hERG Function
View Abstract |
Taming the EDG Receptor Family with the Tango™ Technology
View Abstract |
Using Surface Plasmon Resonance & the Acetylcholine Binding Protein to Screen for Ligands for the Nicotinic Acetylcholine Receptor
View Abstract |
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| P13 Target Biology and Screening Kinases |
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A Kinase Focused RNAi Screen Identifies Novel Mediators of Apoptosis
View Abstract |
A Quantitative Analysis of Kinase Inhibitor Selectivity
View Abstract |
ADPHunter™ Plus Extended Application for Detection of GDP & UDP Production
View Abstract |
Advances in HTS Methods for Interrogation of the PI3K/Akt/mTOR Pathway
View Abstract |
An Optimized ADP Accumulation Assay For PI3 Kinase Primary Screening & Inhibitor Characterization
View Abstract |
Analysis of Kinase Inhibitors using a Large Array of Signaling Antibodies & High-content Screening.
View Abstract |
Beyond Kinases Interrogating the Purinome
View Abstract |
Biochemical Assays for Selectivity Profiling Across the Entire PI3 Kinase Family
View Abstract |
Chemical-Kinomic Approach to Analyze the Selectivity of Kinase Inhibitors
View Abstract |
Development of a High-Throughput LanthaScreen Assay for DNA-dependent Protein Kinase
View Abstract |
Development of an Automated AlphaScreen for Detection of MEK Phosphorylation in a Transiently Transfected Cellular Model
View Abstract |
Development of COT, mTOR & NEK6 Kinase Assays Using the LANCE® Ultra ULight™-p70 S6K (Thr389) Peptide
View Abstract |
Further Characterization of BIRB0796 using Multiple Target Class Profiling
View Abstract |
High-Throughput Screening for c-Jun N-terminal Kinase Inhibitors Using AlphaScreen in a 1536-well Format
View Abstract |
Homogeneous Time-Resolved Fluorescence-Based Assay for Phosphorylated Peptides Using a Generic Binder
View Abstract |
HTRF as a Reliable Platform for Large Scale Kinase Profiling
View Abstract |
HTRF® Transcreener™ ADP Assay The New Solution for ADP Detection
View Abstract |
Interrogation of the National Institutes of Health Small Molecule Repository for Protein Kinase D Inhibitors
View Abstract |
Kinase Assay Development Using Acoustic Droplet Ejection Technology
View Abstract |
Kinase Inhibitor Profiling & Compound Characterization on a Microfluidic Mobility-Shift Platform
View Abstract |
Kinase Selectivity Profiling on EZ Reader™ – 144 Kinases Against 12 Compounds in a Day.
View Abstract |
Luminescent Assay Optimization, Kinase Profiling, & uHTS Application
View Abstract |
PathHunter™ Protein Interaction Assays for Analysis of Receptor Kinase Dimerization in Whole Cells.
View Abstract |
Rapid Improvement of Protein Stability by Thermal Profiling
View Abstract |
Screening of a Kinase Enzyme Utilizing IMAP Assay & EnVision Multi-format Plate Reader Technologies.
View Abstract |
Serine/Threonine Kinase Profiling using the LANCE® Ultra KinaSelect™ Ser/Thr Kit
View Abstract |
Steady State Characterization of Death Associated Protein Kinase 1 Using Microfluidic Technology
View Abstract |
Three Kinase Screening Assays Using a Generic ADP Detection Method
View Abstract |
Tools & Processes to Drive Data Quality & Throughput for Biochemical & Cellular Compound Profiling
View Abstract |
Use of IMAP TR-FRET Detection Mode for the IMAP AGC & CAMK Group Substrate Finder
View Abstract |
Use of IMAP TR-FRET Detection Mode for the IMAP Tyrosine Kinase Group Substrate Finder
View Abstract |
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| P14 Target Biology and Screening Other Targets |
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A Bioactivity Screen to Identify Novel Toll-Like Receptor Peptide Agonists for Use as Vaccine Adjuvants
View Abstract |
A High-Throughput Screening Assay to Identify Novel Compounds that Differentially Inhibit Cell Proliferation of ARMS & ERMS
View Abstract |
A Quantitative High-Throughput Screen for LMNA Splicing Modulators
View Abstract |
Addressing the Tractability of Difficult Viral Targets Approaches Toward the Discovery of Antivirals for Lethal RNA Viruses that Require Biocontainment
View Abstract |
Antagonizing mPGES-1 Developing a High-Throughput Screening Assay
View Abstract |
Antituberculosis High-Throughput Dug Screening at Southern Research Institute
View Abstract |
Application of the Calcium-Sensitive Reporter Photina® to Generate HTS Assays for Na/Ca2+ Exchangers.
View Abstract |
Application of the Transcreener™ AMP/GMP Assay for Interrogating Ubiquitinylation Cascades
View Abstract |
Complementary Cell-Based Screens Identify Specific Inhibitors of the Unfolded Protein Response Apoptotic Sub-Pathway and Reduce False Positive Hits
View Abstract |
Development of a Novel High-Throughput Screening Assay to Identify both Agonist/potentiator & Antagonist of Pregnane X Receptor (PXR)
View Abstract |
Drug Discovery for Muscular Dystrophies
View Abstract |
From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction through the HIV-1 Integrase / human LEDGF-Case Study.
View Abstract |
From Target Identification to the Molecule Walking the Way in Protein-Protein Interaction Through the HIV-1 Integrase / LEDGF-Case Study
View Abstract |
High-throughput Screening Identifies Novel Inhibitors for Bacillus Anthracis O-succinylbenzoyl-CoA Synthetase
View Abstract |
High-Throughput Screening of HAUSP Inhibitors Using the TR-FRET Based DUB Substrate
View Abstract |
HTRF® Deacetylation Assay A new solution for HDAC/SIRT Screening
View Abstract |
Human Anti-Angiogenesis High-Throughput Screening Assay in 384-Well Format
View Abstract |
Identification of MMP-12 Inhibitors by a Biosensor-Based Screening of a Fragment Library
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Identification of Novel Therapeutics for Treatment of Huntington’s Disease – a Phenotypic Screening Cascade
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Mechanistic evaluation of natural product inhibitors of HIV-1 RNase
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MRC Technology’s Drug Discovery Group; a Mechanism for De-risking Novel Targets Emerging from Academia.
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Multiplexing Fluorescent & Chemiluminescent Live Cell Reporters to Dissect NFkB Signal Transduction Requirements
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PathHunter™ NHR Protein Interaction Cell Lines Study Nuclear Hormone Receptors Without Using Reporter Gene Assays
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Permeability Studies Of Coumarins With New Modified Caco-2 Cell Model
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Phosphodiesterases A Novel Microfluidic Mobility-Shift Assay for Inhibitor Screening & Profiling
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Purification & Enzymatic Characterization of Recombinant ADAMTS-5 in Aggrecan based MSD Assay
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Screening against Proteases Comparison of QFRET Substrates & Miniaturization of a Plasma Protein Shift Assay
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Screening for Modulators of Notch Signaling using a Luciferase Complementation-Based Reporter
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Screening of Antimicrobial Compounds in Fungal Extracts against Gram-positive & Gram-negative Bacteria
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Screening the NIH’s Compound Library to Identify Inhibitor Probes of Human Immunodeficiency Virus Reverse Transcriptase-associated Ribonuclease H Activity.
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Strategies for Improving the Impact of High-Throughput Screening Campaigns
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The Southern Research Molecular Libraries Screening Center
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The use of Isothrmal Titration Calorimetry to Determine Enzyme Kinetic Constants for PP1-gamma Phosphatase
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The Use of QuickZyme™ for the Identification of Novel Inhibitors of Anthrax Lethal Factor
We Report On Our Efforts Using the QuickZyme™ Technology Platform for the Identification of Novel Inhibitors of Anthrax Lethal Factor (ALF)
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Use of a High-Throughput Phosphodiesterase Profiling Platform to Study Inhibitors Selectivity
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| P15 Target Identification and Validation |
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A 1536-well Based AlphaScreen Assay for Tdp1 Inhibitor Identification
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AKAP18 - A Potential Drug Target in Heart Failure Patients?
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Drug Target Discovery In Huntington Disease Cell Death Modifiers Identified With Adenoviral Shrna Technology
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Electroporation-based System for Genome Wide RNAi Screening
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Functional Characterization of Positive Allosteric Modulators of a7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma Cells
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Rapid Generation of Epitope-Specific Recombinant Antibodies Using in vitro Selection Technology
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